
Sialolithiasis is one of the most common pathology of salivary gland in middle-aged patients . Sialoliths are localized in submandibular glands in nearly 80% of the reported cases and they are classified as ‘giant’ in case any dimension exceeds 15 mm. Giant sialolith in submandibular gland is a rare disorder with prevalence of 0.1% in population. The aim of this article is to report the case of a patient suffering from sialolithiasis caused by giant salivary calculi in Wharton’s duct and also review of literature on sialolithiasis. The diagnostic approach was done by occlusal radiography, orthopantamography and ultrasonogram and the excision was performed under general anesthesia to remove the atrophied submandibular gland and a giant sialolith of 28mm length localized in the Wharton’s duct.