Kidney morphological changesin patients with asymptomatichyperuricemia and chronic kidney disease

Background: The aim of the study is to take into account the relationship between asymptomatic hyperuricemia (a HU) and morphological changes in the kidneys. Materials and Methods: A retrospective analysis of kidney biopsy of 110 patients divided into two groups: with a HU (n = 62) and non- HU (n = 48).We analyzed each morphological change separately in the respective groups, then the data were compared between the two groups. A multifactorial analysis was performed between the degree of the morphological changes and proteinuria (PU), systolic blood pressure (SBP), and diastolic blood pressure (DBP), that are factors for non-immune progression of chronic kidney disease (CKD). Results: When comparing only the morphological changes between the two groups, no statistically significant difference was found. Patients with a HU and severe mesangial cells proliferation, the PU was higher - 4.31 +/- 4.6 g /24 h if compare with non-HU 2.64 +/- 2.28 g /24 h. The same dependence is reported in the presence of significant interstitial infiltrates and interstitial fibrosis, and the marked changes in extraglomerular vessels. Expression of tubular atrophy in a HU group is associated with higher SBP than the control group: 143.75 +/- 18.47 mmHg and 117.7 +/- 35.94 mmHg. Conclusions: Correlation was established in patients with a HUand pronounced interstitial fibrosis, and with changes in extraglomerular vessels. Patients with a HU and interstitial infiltrates had higher PU. The association of a HU with some morphological changes results with higher SBP, DBP, and PU that are factors relevant to the progression of CKD.