“Evaluation of demineralized freeze dried allogenic bone graft (dfdb) with and without platelet rich fibrinin (prf) in post surgical jaw defect: Comparative prospective study

Aims & Objectives: The aim of the study was to evaluate the healing of the facial bone defect with demineralized freeze dried allogenic bone graft (DFDB) individually and with platelet rich fibrinin (PRF). Materials and Methods: The study comprised of a total of 20 subjects with maxillofacial defects divided into two equal groups (A & B) of 10 each. Treated with DFDB and DFDB with PRF respectively. Clinical parameters like Post-operative pain (Visual Analog Scale), swelling, infection, implant rejection, mouth opening were compared for both groups and Radiographic evaluation at 1 week, 6th week, 12 week intervals was done to evaluate the radiodensity of bone formed. Results: Genderwise, Difference in age, Difference in grades of pain (p=0.368), swelling (p=0.531), post-operative infection. Different evidence of calcification at 3 weeks (p=0.136) shows result statistically insignificant while at 6 weeks and 12 weeks it was found to be statistically significant (p<0.001). Evidence of Bone Formation was slight at 3 weeks, moderate at 6 weeks and marked in group B at 12 weeks period with statistically significant. Total bridging of gap by normal bone was statistically insignificant at 3 & 6 weeks and statistically significant at 12 weeks time period. Change in total bridging gap by normal bone was statistically significant in both the groups. Conclusion: DFDB when used with PRF induces early calcification, bone formation and bone bridging. Also handling, placement and retention qualities of DFDB graft is improved with PRF.