Salinity is one of the major constraints in agriculture which affects the plant growth and productivity. The high concentration of salt in soil causes ion imbalance leading to osmotic stress in plants which further leads to oxidative damage in the plant cell via ROS production. ROS caused damage to the lipids, proteins and nucleic acids. Plants have developed certain mechanisms to resist the oxidative damage caused due to salinity. The genes conferring salinity stress resistances provide foundation for scientific improvement of the plants productivity under arid condition and contribute to improvement and stabilization of plant yield. Molecular genetics and plant transformation has helped in generating salt tolerant plant by modifying the signal cascades, biochemical pathways, specific protein expression or by altering the gene response under natural condition. Salt tolerant transgenic crops have been developed and more work is going on in this direction.