Anxiolytic effects of hydroalcohol extract of feronia limonia (wood apple) fruit in mice model of anxiety

The anxiolytic effect of hydroalcohol extract of Feronia limonia (HEF) was investigated in the present study. The extract was orally administered to the Balb/C mice for a period of 7 days at the graded dose of 50, 100 and 200 mg/kg, bd.wt. Mice treated with 100 and 200 mg/kg bd.wt extract, significantly increased the time spent by the mice in open arm in elevated plus maze test (EPM), increased the square crossing in open field test (OFT) and increased the numbers of punished lick and shocks received in Vogels conflict test (VCT). Treatment with HEF also reduced the corticosterone levels in plasma, and GABA in brain tissues of mice. Over all the peak anxiolytic effects was obtained at the dose of 100 mg/kg bd.wt in mice. Thus, the present findings suggest the use of FLH as a potential herbal anxiolytic agent.