
Sex fixing of mammalian progenies is one of the most fascinating subjects ever reported and if properly developed and put to application value, it can be a formidable tool in increasing dairy productivity as well as ensuring considerable economic and social benefits. There have been many recorded attempts to produce sexed off-springs in mammals and most of them involved semen sexing methodologies. The present methodology involves a novel in vivo technology duly patented in a variey of countries world over including USA, Canada, Australia etc and which uses the administration of a dosage form which has active ingredients like monosodium ethanoate and ethanoic acid in solution form which when given orally a little while before insemination to females of dairy animals, cows and buffaloes; yields female off-springs with impressive success rate. A huge trial of this methodology was conducted in real field conditions in Punjab spread over a vast area covering nearly ten districts involving variations in temperature and climatic habitat conditions and the outcome was impressive. The analysis and impact factor calculation of such a discovery were undertaken to assess the application value of such a drug discovery with reference to Indian conditions especially with a view to North Indian terrains like Punjab.