Leukemias represent a varied group of malignancies of hematopoietic stem cell origin. A subgroup of thesemalignancies is represented by the myeloid leukemias which generally affect adults.Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of pluripotent haemopoietic stem cells, affecting mature myeloid white blood cells. More than 90% of cases of CML result from a cytogenetic aberration known as the Philadelphia chromosome. CML accounts for 15% of all leukemias and males are more commonly affected than females. Most patients with CML are older than 60 years of age. It is a rare case as its annual incidence is one to two cases per 100000. A case of CML having all the characteristic features of the disease is presented. Due to its high morbidity rate, early diagnosis and appropriate medical therapy are essential andthe oral signs and symptoms may reflect an undetected serious systemic disease.
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