Circulating levels of resistin and +299 (G>A) Resistin gene polymorphism in type 2 diabetes mellitus, a study from north India

Introduction: Obesity is a risk factor for diabetes mellitus. Resistin, an adipokine explains the link between obesity and diabetes. The present study was conducted to explore the association between resistin gene polymorphism and type 2 diabetes mellitus (DM). Study Design: It was a case control study consisted of 90 Indian subjects divided into three groups as cases (n=30), obese person without diabetes (n=30) and healthy controls (n=30). Following parameters were measured: age, body mass index (BMI), waist hip ratio (WHR), lipid profile, plasma glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) and resistin. Comparison of data was done by using one way ANOVA and odd’s ratio was determined to calculate the risk. Results: Serum resistin was significantly higher in cases of type 2 diabetes with +299 (G>A) genotypes. Resistin gene polymorphism +299 (G>A) is a significant risk for type 2 diabetes. Conclusion: Resistin gene polymorphism +299(G>A) has an association with diabetes and increase the susceptibility of type 2 DM.