Background: Lung cancer is one of the commonest and most lethal cancer throughout the world. Tobacco smoking continues to be the leading cause of lung cancer worldwide. An increase incidence of lung cancer has been observed in India. Objective: The aim of this study was to find out the demographic and clinico-pathological and radiological profile of diagnosed lung cancer patients and its relation to smoking habit in area of western Rajasthan, Jodhpur, India. Materials and Methods: We performed a retrospective analysis of histo-pathologically proven cases of lung cancer in our hospital from 2012 to 2014. Results: Out of 310 patients, male 278 and female 32, 83.2 % were smoker and only 7.41 % were ≤40 years of age. Smoking was the major risk factor for lung cancer. The most frequent symptom was cough (59.35) followed by chest pain (50.32). The most common radiological presentation was mass lesion (30.96%), followed by collapse in (30.22%). Squamous cell carcinoma (50.32%) was most common histopathological type followed by adenocarcinoma (32.90%). Conclusion: It was found that squamous cell carcinoma was the most frequent histopathological type. Adenocarcinoma was the predominate type below 50 years and squamous cell carcinoma was more common in age above 50 years. Smoking still remain the major risk factor.