Background: Pandemic influenza A (H1N1) 2009 has posed aserious public health challenge world-wide. Genetic re-assortments in the influenza virus cause fast and unpredictable leading to recurrent epidemics of febrile respiratory disease every 1 to 3 years. Aim & Objectives: To study the clinico-epidemiological profile of the swine flu influenza A H1N1. To study the certain epidemiological correlates affecting the outcome of disease. Material & Methods: A descriptive study conducted on suspected swine flu Influenza A H1N1 patients admitted in infectious disease ward (IDW). The personal interview technique combined with clinical examination was done uniformly using the pre-tested structured questionnaire. Results: Out of total patients admitted in IDW, 60.34% were females & 39.66% were males. 55.17% of patients were from urban area while 44.83% from rural area. Out of 58 patients 12 patients were confirmed cases of swine flu influenza A H1N1, while 46 were confirmed negative. Proportion of confirmed cases of swine flu influenza A H1N1 83.33% in females as compared to 16.67% in males. Influenza A H1N1 resulted in death of 05 (41.67%) confirmed cases among total 12 confirmed cases. Out of 12 (100%) confirmed swine flu influenza A H1N1 cases 09 (75%) expired patients had one or other predisposing factor associated. Conclusion: Cough, running nose, body ache and fever are the most common symptoms with which the patients usually present. The risk of death was seen more in patients associated with predisposing factors.