Purpose: To assess bone regeneration in peri-implant bone defects grafted by demineralized freeze–dried bone graft using platelet-rich plasma and platelet-rich fibrin. Methods: Twenty patients who were to be rehabilitated by implant supported prosthesis were considered for the study. During placement of implants, the implant site was assessed for any peri implant defect and these patients with peri implant defect were divided into two equal groups randomly, one group to receive platelet-rich plasma with bone graft and other group to receive platelet-rich fibrin with bone graft. Immediate and three months post-operative CBCT was taken to compare the bone formation in the peri-implant defect. The CBCT image is screen captured and imported into a picture editing software and linear measurements of the bone is measured. Results: The mean vertical facial bone height formed by using Platelet rich plasma and Platelet rich fibrin with bone graft was 0.17+ 0.19 mm and 0.56 + 0.38 mm respectively(P = 0.015). The mean value in vertical lingual bone height formed was 0.15 + 0.27 mm and 0.72 + 0.68 mm for Platelet rich plasma and Platelet rich fibrin respectively (P = 0.033). Conclusion: Based on the results it was concluded that Platelet rich fibrin is efficacious in the treatment of a peri- implant defect.
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