Comparative study of triphala and trikatu on obesity induced oxidative stress in heart of albino rats

Objective: The purpose of the present study was to evaluate the cardioprotective and antioxidant properties of Triphala and Trikatu against obesity induced cadiotoxicity in female albino rats. This was compared with standard herbal (ayurslim) and synthetic (sibutrex10TM) anti-obesity drugs. Methods: Animals were divided in to three groups. Group I: Control group, Group II: Short duration group, Group III: Long duration group. Group II and Group III were further sub-divided into six sub groups, each group consisting of five animals. 1. Obesity control - The animals received atherogenic diet as an oral dose. 2. Obesity + Triphala - The animals received atherogenic diet + 8.3 mg triphala / 100g body weight / day, as an oral dose. 3. Obesity + Trikatu - The animals received atherogenic diet + 4.16 mg. of trikatu /100g. body weight / day, as an oral dose. 4. Obesity + Triphala and Trikatu - The animals received atherogenic diet + 4.15 mg of triphala and 2.08 mg of trikatu respectively/ 100g. body weight / day, as an oral dose. 5. Obesity + Ayurslim - The animals received atherogenic diet + 13.3mg. of ayurslim / 100g. body weight / day, as an oral dose. 6. Obesity + Sibutrex10TM - The animals received atherogenic diet + 0.17mg. of sibutrex10TM / 100g. body weight / day, as an oral dose. Result: The present study showed that obesity had caused an significant (P<0.05) decrease in the activities of antioxidant enzymes like superoxide dismutase, catalase and glutathione in heart. There was significant (P<0.05) increase in lipid peroxidation in heart tissues. Conclusion: The oral administration of Triphla and trikatu were more effective in the restoration of obesity induced oxidative stress in the heart.