Background: Phlebitis is inflammation of the vein wall that is the most common complication of intravenous infusion therapy. The incidence of phlebitis in hospitalized patients receiving IV therapy has been reported to be as high as 80%. Aim: To find out the most effective applicant for reduction of phlebitis in comparison of Heparinoid and Ichthammol glycerine. Setting and Design: Christian Medical College and Hospital, Ludhiana, Punjab and Non-experimental comparative research design with quantitative approach. Material and Methods: Total 60 subjects (30 with Heparinoid and 30 with Ichthammol Glycerine application-age, gender and type of disease condition- matched). The participants were selected from critical care areas of Christian Medical hospital, Ludhiana. Data was collected with using Modified Visual Infusion Scale and Standardized Numerical Pain Intensity assessment scale. Result: In Heparinoid group mean phlebitis score before application was 10.14 and after 48 hours it decreased to 2.37 but on the other hand in Ichthammol glycerine application group mean phlebitis score was 10.51 which decreased to 1.50 after 48 hours of application. Before application, after 24 hours and after 48 hours of application ‘t’ value between Heparinoid and Ichthammol application group was 0.71, 0.63 and 1.68 respectively, which were not significant at p<0.05 level of significance. Conclusion: Both the applications were effective in reducing IV induced phlebitis.