Sahaja Yoga is a unique method of meditation based on an experience called Self Realization (Kundalini awakening) and aims at achieving holistic health care for people, Gupta et al (2015) A study was designed to assess the effect of Sahaja Yoga meditation on Blood Pressure (B.P), plasma MDA levels and blood thiol level in 40 hyper- reactors to cold pressor test (in the age group of 20-25 years ) and was compared with B.P., plasma MDA levels and blood thiol levels in same hyper- reactors before starting the yoga. Blood samples were taken before starting the yoga and 90 days after Yoga practicing. The value of B.P., Plasma MDA level was found to be significantly reduced (p <0.001) and blood thiol level was raised significantly (p< 0.001) after 90days of Sahaja yoga. Similarly, Reduction in oxidative stress suggests that Sahaja Yoga can be used as a complimentary therapy in the management of cardiovascular diseases, diabetes and stress related disorders.