The purpose of this study was to examine the effectiveness of life skill training on mental health, positive thinking and marital adjustment of married women in mobilization bases of Karaj city. The study was an experimental one with pre-test-posttest control group design. The data were collected by running the General Health Questionnaire (Goldberg and Hiller, 1979) , Munch's scale of happiness (Kuzma and Stones, 2000) and marital adjustment scale (Spanir , 1976 ) on 265 women who were selected through random clustering method. Out of 265 women, 138 persons were at a lower level at the same time in terms of the mentioned variables. Then, 80 participants were selected through simple random sampling technique and assigned into experimental and control group randomly. Experimental group was subjected to life skills training in 10 session including3 skills of self-awareness, effective communication, and problem-solving. At the end of training, a posttest was conducted on two groups, and the number of participants was 60 after falling and dropping. Data were analyzed using multivariate analysis of covariance. Results showed that the effect of life skill training on the combined dependent variable and also dependent variables was significant independently. The findings indicated the improvement of mental health, positive thinking, and marital adjustment of married women due to the impact of skill life training. Effect size analysis showed that skill life training affected positive thinking more.