The term Ama refers to raw, unripe, unprocessed or improperly digested condition of food substances probably due to the result of mandagni (hypo functioning of Agni). Ayurveda is basically more oriented toward the management of lifestyle disorders which are in prominence due to stress-related phenomena and some other reasons among certain age groups in the society. Agni is the root cause of cause of Ayu, Bala and Varna. Agni may disturbed by life style disorders. Mandagni is the root cause of all diseases and is a causative factor for the production of Ama. Ama is described by all Acharya but the greatest clinical detail for this entity Ama has been for the first time described by Acharya Vagbhatta. It is very necessary how we can diagnose Ama formed in body for the purpose of treatment of disease. Ama acts as an antigen and possesses the potency to induce immunological reaction in a susceptible individual and Ama can also be generated within the body (endogenous ama) by virtue of excessively vitiated doshas (autoimmune). This paper will discuss about the various clinical aspect of Ama (Apakwa food) and its impact over body.