The fact that the periodontium is anatomically interrelated with the dental pulp by virtue of apical foramina and lateral canals creates pathways for exchange of noxious agents between the two tissue compartments when either or both of the tissues are diseased. Proper diagnosis of the various disorders affecting the periodontium and the pulp is important to exclude unnecessary and even detrimental treatment. This is a clinical case report of an enododontic-periodontic lesion in relation to upper left central incisor. Root canal treatment had been done with the respected tooth, but the lesion showed no sign of healing resulting in draining sinus and increasing pocket depth. Radiographic examination revealed extension of inflammation into periodontal space. Periodontal flap surgery was performed and a 10mm defect was found and filled with bone graft mixed with platelet rich fibrin (prf). Patient was reviewed for six months which showed uneventful healing, no recurrence of the lesion and significant bonefill in the region.