Madhumeha has been described as maharoga in ayurvedic classics. It is one of the most alarming disease and possesses a special place in medical science due to its high prevalence in the society and increased incidence. In Ayurveda, Madhumeha has been described as one among one of the 20 types of Prameha and is a sub-type of VatikaPrameha. The factors which provoke Vata directly cause Apatarpanajanya Madhumeha and the factors which provoke Kapha and Pitta cause Santarpanajanya Madhumeha. In the former type the patients are usually asthenic can be correlated with Type I DM and in the latter type patients are obese and can be equated with Type II DM. Shodhana is the preferred choice for the elimination of Doshas, thus Virechana karma was selected as Shodhana procedure, which is specific for the elimination of vitiated Pitta Dosha1 as well as Kapha Dosha2. Even for VatavyadhiVirechana is a good treatment.3 The present study was an open trial, which was carried out at R. G. G. P. G. Ayurvedic Hospital, Paprola. The study was conducted in two groups on 10 patients in each group and results were compared. Patients who fulfilled the criteria of assessment of the trial were selected.In group1 patients were given Triphala Ghrita for snehpana as a purvakarma followed by Virechana karma as shodhana chikitsa and Trayushnadi gutika as a shaman yog for 30 days after Virechana. In group2 only Trayushnadi gutika was given as shamana yoga for 45 days. 10 Patients in age group between 25-70 years having clinical features of Diabetes Mellitus were taken in each group. After evaluating the total effect of therapies comparative result of Virechana and Trayushnadi gutika (combined therapy) and Trayushnadi gutika (shamana therapy) was seen on Madhumeha.
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