Pollution of POPs, which are carcinogens, has an adverse effect on the environment and human health. One of the crisis regions of Kazakhstan is considered the Aral Sea area. Shalkar and Irgiz villages are located in the ecologically unfavorable zone of the Aral Sea in the territory of Aktobe oblast. On the basis of the obtained sample samples, we conducted research on the residual quantities of persistent organic pollutants (POPs), hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), PCBs and dioxins. Calculations of carcinogenic risks revealed that total individual carcinogenic risk (CR sum) in the village of Shalkar when exposed to POPs (most of them are PCBs, dioxins, HCH) via different routes from various environments was 2,0x10-5and for the village of Igriz, 5,2x10-4. The evaluation of the carcinogenic risks we have received is assessed by their acceptability and allows us to relate the village of Shalkarto the second-range of risk, and the village of Irgiz to the third - range risk, which indicates the unacceptability of people's lives. This necessarily requires constant monitoring with the inclusion of all environmental objects, otherwise we may lose an entire generation of children who already today suffer from diseases associated with exposure to POPs (eye diseases, endocrine system diseases and diabetes mellitus).