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The full 9 stepped cycle of proton conductance and antiobesity mechanism of proton leakage from erythrocyte membrane surroundings

Author: 
Ambaga, M. and Tumen-Ulzii, A.
Subject Area: 
Health Sciences
Abstract: 

The accumulative capacity of erythrocyte membrane surroundings in relation to free protons, formed in the full 9 stepped cycle of proton conductance is one of more powerful factors influencing the antiobesity mechanism. The accumulation of protons inside erythrocyte membrane surroundings are strongly connected with all previous stages of transferring of protons within the full cycle of proton conductance, which conducted as follows as the second stage of proton conductance, where formed CO2 and the seventh stage of proton conductance, where formed metabolic water - H2O in the result of oxidation of protons by activated oxygens, after this have been occurred the reaction between CO2 and H2O with formation of H2CO3 and dissociation reaction withformation of HCO3. HCO3 formed during this reaction have been entered to the erythrocyte membrane surroundings, bearing some parts of protons, released from food substrates. In such way, protons released from food molecules passing all previous 7 stages of the full cycle of proton conductance have been created the preconditon of biosynthesis of fatty acids with participation of HADH, FADH2 (HADH + ATP = NADPH) formed during second stage of full cycle and reached to final 9-th stage as erythrocyte membrane surroundings. This explanation gives the new idea, that if we can succeeded to cause the controlled proton leakage from erythrocyte membrane surroundings, which thereby would lead to diminish the proton gradient in the intermembrane space of mitochondria and also diminish the following transfer of proton to matrix through ATP synthase (sixth stage) and to decrease the fatty acid synthesis owing to relatively shortage of reducing agent as NADPH.

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