Introduction and objectives: Grapefruit juice is recommended daily for normal individual and patients with obesity, dyslipidemia, insulin resistant, cancer with a promising hope of its beneficial effect. This study investigates the effect of daily intake of grapefruit on body weight, lipid profile and cerebellar function. Material and Methods: 40 Albino rats divided into four groups and followed up for 14 days. Control group (Cgp) took pure water; Experimental group (E. gp1, 2, 3) took 10 ml, 20 ml and 30 ml of grapefruit juice daily respectively. Body weight, lipid profile and motor coordination of the groups were assessed as well as the histological study of the cerebellum. Results: daily consumption of grapefruit /14 days in rat showed a non- statistical reduction in body weight, cholesterol, triglyceride, LDL levels and an increase in HDL level; accompanied by atrophy in the granular layer of the cerebellum and a decrease in the number of Purkinje cells. Conclusion and recommendations: daily consumption of grapefruit juice reduced body weight, improved lipid profile in rats yet affected their motor coordination. We recommend further research at the cellular and molecular level with large sample size before we can generalize the findings.
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