Field experiments were conducted at Crop Research Centre of Sardar Vallabhbhai Patel University of Agriculture and Technology, Meerut, Uttar Pradesh, India during 2013-14 and 2014-15 using randomized block design to evaluate some novel insecticides against root borer, Emmalocera depressella and their effect on natural enemies’ population in sugarcane. All the treatments were found significantly effective in reducing the infestation of root borer compared with control. Chlorantraniliprole 0.4 GR @ 18 kg/ha was found most effective in reducing the incidence of root borer among all treatments. The treatment chlorpyriphos 25 EC @ 5lit/ha was recorded least effective in minimizing the pest problem.