The study was designed with the aim to evaluate Econazole nitrate Microemulgel for a treatment of fungal infection. Microemulgel is isotropic mixtures of oil, water and emulsifying agent. Recently, Microemulgel has emerged as one of the most interesting topical preparation in the field of pharmaceutical sciences. The use of Microemulgel as a delivery system has several advantages such as ease of administration, increased residence time of drug at applied site, better drug release, good thermodynamic stability and higher transdermal permeability over conventional formulation. The objective of the study was to prepare Microemulgel of Econazole nitrate, using Carbopol 940 and HPMC [9004-65-3] as a gelling agent, oil phase, preservative, emulsifying agent and buffers was used as penetration enhancer. All the prepared Microemulgel formulations showed acceptable physical properties, appearance, spreadability, homogeneity, viscosity, pH, and Formulations were tested for drug excipient interactions subjecting to FTIR Spectral analysis, Skin irritation test, In-vitro drug diffusion studies showed 98.89% for F9 formulation maximum release of drug in 120 minutes and Stability Studies. The clinical evaluation proved the efficacy and tolerability of this preparation in the treatment of various topical fungal infections. Topical antifungal treatment was successfully achieved with Econazole nitrate microemulgel.
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