
Background: In developing countries there is a lack of data on estimation of incidence of sepsis. Global studies suggests that, it is required to address the magnitude of this problem with mortality rate ranging from 20-60%. Aim and Objectives: to evaluate the incidence rate, microbial causative agent, drug susceptibility profile of causative bacteria and estimate the predisposing factors and patient outcome of the cases of septicaemia. Method: Blood culture of inpatient admissions from a period of July 2013 to August 2014, suspected of septicaemia was processed and data analyzed. Result: Out of 1714 blood culture specimen 490 were found to be positive. Conclusion: The incidence rate of septicaemia in our hospital was found to be 7.4 per thousand per year. The incidence rate was highest in paediatric department. The most commonly isolated organisms were gram positive (46.7%), followed by gram negative (43.8%) and candida species (9.5%). The most effective antibiotic for Gram positive organism in this hospital was vancomycin and amikacin. While, effective antibiotic for Gram negative bacteria were colistin, netilmicin, meropenem and imipenem. The proportional mortality rate for patients with septicaemia was 14.4%.