Background: pregnant woman must have adequate and nutritious nutrition during pregnancy for the process of growth and development of the fetus. Pregnant women who experience malnutrition during pregnancy such as lack of iron intake, it will cause adverse effects on the mother and fetal growth and development. Lack of iron intake in pregnant women can cause anemia. Aims: to analyze the influences of age, antenatal care visit and adherence with Fe tablet consumption toward the incidence of anemia in pregnant women. Methods: This study was observational analytic with case control research design. Respondents were 88 using by purposive sampling. Collecting data were questionnaires guideline. Analysis data were Chi-square and Manova. Results: there was a significant influence between age on the incidence of anemia in pregnant women p=<0.001, there was a significant influence between ANC visits to the incidence of anemia in pregnant women in the Medan Johor Health Center Working Area in 2019, p=<0.001, and there was a significant influence between adherence to consumption of Fe tablets to the incidence of anemia in pregnant women in the Medan Johor Health Center Working Area in 2019 p=<0.001. Conclusion: to overcome the problem of anemia in pregnancy is by early detection of complications and complications in pregnancy through the ANC service program, in the form of a pregnancy check-up of at least four visits namely at least once in the first trimester, once second trimester and two in the third trimester. Pregnant women who do not routinely make ANC visits are at risk of developing complications in pregnancy, one of which is the incidence of anemia.