Instructional resources or materials including human and audio-visual are essential components of a curriculum. They are designed to help the teachers to understand and implement the ideas contained in the new curriculum. The main purpose of the study was to investigate the factors that affect the teaching and learning of life skills curriculum in secondary schools within Eldoret East District. This paper evaluates the instructional resources used by teachers. The study was based on Gagne’s theory of instruction which states that learning is influenced by both internal and external conditions of learning in an educational setting. The study adopted a descriptive survey research design. The techniques used to select the research sample were stratified, purposive and simple random sampling. Two hundred and forty (240) students, 45 teachers and 15 heads of humanities department were selected to participate in the study. To collect data, questionnaire and interview schedule were used. Data collected were coded in Statistical Package for Social Scientists (SPSSv 13.5) and analysed by non parametric Chi-square (χ2) test, descriptive statistics and frequency distribution. The findings were presented in form of tables, charts and graphs. The findings revealed that textbooks were the most available resources for teaching life skills. It is recommended that schools should strive to provide adequate and appropriate instructional materials for LSE. The findings of the study is hoped to benefit teachers of life skills and to guide the policy makers in improving the quality and teaching of life skills curriculum.