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Malondialdehyde level in patients with myocardial infarction (a case control study of 30 patients)
Subject Area:
Life Sciences
Abstract:
Coronary artery disease (CAD) is the leading cause of death worldwide. Many recent studies have shown that anomalies in circulating lipid levels are a predisposing factor for coronary heart disease. Oxidative stress has been implicated in the patho-physiology of CAD. Lipid peroxidation measured as malondialdehyde (MDA) is an indication of the extent of free radical mediated tissue damage. The difference in the malondialdehyde levels between the case and control groups was highly significant (p value < 0.0001) suggesting Malondialdehyde as an important risk factor for myocardial infarction. The difference in Malondialdehyde levels observed between patients with LDL-C > 100 mg % and those with LDL-C < 100 mg % was statistically extremely significant (p value < 0.0001).
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