The polyphenols in pomegranate play important role in exhibiting anti-ageing effects

Pomegranate (Punica granatum L), in addition to its ancient historical uses, has been used in several systems of medicine for a variety of ailments. Pomegranate juice is a polyphenol-rich juice with high antioxidant capacity. It is evident from the previous studies that pomegranate juice has been shown to exert significant antiatherogenic, antioxidant, anti-carcinogenic, and anti-inflammatory effects. The aim of the present study was to validate the skin care properties of P. granatum. The extract exhibited high anti-elastase and collagenase activities at various concentrations indicating the significant anti-wrinkle effect (52.28 and 53.98 % respectively at 100 µg/ml concentration). Further, pomegranate extract was highly effective in protecting the DNA from hydroxyl radical mediated scission. The in silico calculations predicted that lowest energy docked poses of phenolic compounds can interact with catalysis-dependent residues, thus making them possible catalytic inhibitors and of course physiologically active. This study concludes that pomegranate can potentially be used as a readily accessible source of skincare anti-ageing agents and demand the need for extensive research in cosmeceutical applications.