Pro-proliferation prowess of Upregulated jakmip1 in human lung Adenocarcinoma

Gaining insights into the possible functional aspects of relatively unknown genes to tumor genesis may help uncover new cancer biomarkers. Jakmip1, connected to autism spectrum disorders, is relatively new protein that we first demonstrated its ability to activate Wnt/beta catenin pathway and induce increased cervical carcinoma cell proliferation. In this report, we examined the impact of exogenous supplementation of Jakmip1 expression in lung adenocarcinoma. Cells over expressed for Jakmip1and their controls were assayed for their in vitro proliferation potential in CCK-8 and clonogenic assays, before they were implanted subcutaneously in nude mice to monitor tumor growth. Here, we present that up regulation of Jakmip1 increases cell proliferation and induce larger tumor development in xenografts. The acquisition of pro-proliferation prowess following Jakmip1 higher expression paralleled the protein expression of beta catenin and cyclin D1. Collectively, our data avidly suggest that upregulated Jakmip1 wields the potential to promote cancer growth and may be relevant to lung tumorigenesis.