Reversal from neuromuscular blockade

Recovery from the effects of non-depolarising relaxants can occur spontaneously by elimination of the agent either unchanged or after metabolism in general anaesthesia. However, this process may be slow, of variable time and cannot be reliably predicted. It may result in residual curarization. Also, surgical procedures can be of unpredictable duration and may require intense relaxation until near the completion of surgery. Pharmacological antagonism or reversal of NM block is therefore indicated in clinical practice. This can be accomplished with a variety of drugs called as reversal agents.