Back ground: Because of the incidence and the health –related problems of post- menopausal osteoporosis it has become a social problems requiring appropriate management strategies. The present study is an attempt to estimate the levels of calcium, phosphorous, magnesium, sodium, potassium, alkaline phosphatases and vitamin D of post-menopausal osteoporotic women. The present study was carried out to find out the association of minerals with post-menopausal osteoporotic women. Methods: 100 post- menopausal osteoporotic women and 90 non osteoporotic women of age and sex matched healthy controls were obtained from King George Hospital, Visakhapatnam during the period January 2015 to April 2015. The levels of calcium, phosphorous, magnesium, sodium, potassium, alkaline phosphatases and vitamin D were estimated by using kits (Calmagite Method) (For invitro diagnostic use). The data was analyzed by online free calculator(quantpsy.org.) Med calculator (www.open epi.com). Results: The odds ratio shows only small risk for 75-85 years age group of post- menopausal osteoporotic and non osteoporotic women. The odds ratio p-value shows statistically insignificant result with the age of post-menopausal osteoporotic women. For calcium and alkaline phosphotases statistically significant mean p-values were obtained. Conclusion: The study confirms findings of earlier studies carries out in India and other countries. The present study reveals that serum calcium levels are significantly reduced in post-menopausal osteoporotic women than non osteoporotic women, whereas serum ALP levels are significantly increased.