Identification of human skeletal remains is a critical problem and is very important in medico legal and anthropological work. The determination of sex of an individual is important and necessary both in the living and the dead for medico legal and anthropological study purpose. Bones often survive the process of decay and therefore provide the major evidence of human age and sex after death. The mandible is the strongest bone of facial skeleton and the best preserved after death. The mandible is the best suitable bone for the study to determine the sex and age of the human remains. This study based on the known sex of 100dry human mandibles. Various measurements will be taken. The difference between measurements of male mandibles and female mandibles will be calculated by taking the mean value of measurements taken, which will help in determination of sex of the mandible. The mandibular index will be calculated from the measurements between right and left mandibular foramina and mean of measurements betweenmandibular foramen and genial tubercles. All these measurements will help in determining the sex of the mandible, even from fragments we can calculate and determine the sex of human mandible. This is the aim of our study.