
Background: Work-related stress is a serious problem that affects the health and well-being of employees as well as the productivity of organisations. Stress has a huge impact on the performance and productivity of emergency health workers. Paramedics are routinely exposed to a range of highly stressful incidents, as they have to deal with unpredictable and non-specific threats. Objective: The objective of the study was to explored the factors associated with stress and identified the effects of stress and burnout on Red Crescent ambulance workers. Method: A cross-sectional study was conducted among ambulance workers in Riyadh, Saudi Red Crescent centres across four regions of the Ar-Riyadh province of Saudi Arabia. Structured Questions about sociodemographic information, working conditions, the level of burnout, and job stress were included in the questionnaire. Result: A total of 627 employees participated in the study, 95% participant were Emergency medical technician, 46.7% participants had worked for their present employer from 3 years to less than 6 years and 2.6% worked more than 12 years. Full - time permanent employee was 41.6%, and rotating 12-hours shift 64.6%. Corresponding with the result found in this study, the risks of stress, anxiety, and depression faced by a paramedic were usually associated with long working hours, unpredictable emergencies, and changing sleep patterns. Conclusion: Stress level and work-related burnout was a leading cause of poor performance and resulted in the inability of employees to perform assigned tasks.