
Meningitis is the inflammation of the meninges, a protective membrane that surrounds the brain and the spinal cord. To reduce the mortality and morbidity owing to meningitis, an early establishment of the diagnosis and early institution of therapy are imperative. Therefore, we conducted this study with the main objectives of examining the specific clinical features with which our patients in a tertiary care setting presented, and also the abnormalities in the CSF biochemistry. Aim of this study is to study the clinical profile and CSF examination in patients of meningitis. The study was a observational randomised case study carried out from September 2017 to September 2018 at C.U. Shah Medical College and Hospital, Surendranagar (Gujarat), which is a tertiary care centre. Most of the patients were in the age group of 21-40 years (42%) of age. This is followed by 41-60 years (28%) of age. We observed a male preponderance among the cases, 31(62%) of males as compared to 19(38%) of females. Among mean value of CSF biochemistry highest mean lymphocytes count and mean glucose level were observed in the patients of viral meningitis, highest mean protein level and mean leukocytes count were seen in bacterial meningitis and highest mean ADA level was seen in tuberculous meningitis.