A study of variation of serum uric acid levels in patients with and without diabetes mellitus who have normal kidney function

Background: Several epidemiologic studies have reported that high serum levels of uric acid are strongly associated with prevalent health condition such as obesity, insulin resistance, metabolic syndrome essential hypertension and renal disease. This study aimed to investigate the level of uric acid in type 2 diabetes mellitus patients and in non-diabetes controls with normal kidney function. This study also included the correlation of serum uric acid with glucose, creatinine, age, gender and duration of diabetes. Method: A single-centric, hospital based, cross-sectional study was conducted for 6 months. The study had two groups: 92 patients with diabetes and 92 patients without diabetes. All the patients were having normal kidney function. The patients were evaluated for fasting blood sugar (FBS), post prandial blood sugar (PPBS) and serum uric acid levels. Result: No significant difference in mean uric acid levels were reported between diabetes and non-diabetes population. No significant correlation of uric acid levels with age, gender and glucose levels (FBS and PPBS) were not reported, but the significant positive correlation of uric and duration of diabetes were observed in male diabetes population. Conclusion: Since the cross sectional study shows confounding data, the implication of uric acid levels in diabetes mellitus as well as in pre-diabetes need to be further investigated.