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Synthesis and biological study of novel triazole analogues of benzothiazepines
Subject Area:
Life Sciences
Abstract:
A series of new 4-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-2-aryl-2,3-dihydro-1,5-benzo- thiazepine 6(a-j) have been synthesized from (E)-1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3-aryl-2-propen-1-one 5(a-j). The structures of the synthesized compounds have been confirmed via IR, 1H NMR, 13C NMR and MS spectral analyses. Further, all compounds have been assayed for their antibacterial activity against Gram-positive and Gram-negative bactiria. The antibacterial screening data revealed that, compounds 6 which contain 4-chlorophenyl (6b), 4-methoxyphenyl (6e) and 2-hydroxyphenyl (6f) moieties on benzothiazepine ring might be the reason for the significant inhibitory activity. Most of these new compounds showed appreciable activity against test bacteria and emerged as potential molecules for further development.
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