This protocol deals with novel method for the synthesis and characterization of Zeolite Linde type- L by hydrothermal method using PTFE-lined stainless steel autoclave. The synthesized zeolite LTL was used as catalyst for the Hantzsch reaction mechanism for the synthesis of Acridine-1, 8- dione derivatives. Efficiency of Zeolite-LTL has been observed at various parameters (i.e. different solvent, temperature, catalyst concentration, time interval and catalytic recycling) over the percentage yield of various derivatives. Synthesis of 9, 10-Diarylacridine-1, 8-dione was carried out by single-pot Hantzsch condensation reaction, which includes three component reactants i.e. aldehyde, amine and 5, 5-Dimethyl-1, 3- cyclohexanedione (dimedone). Expeditious with excellent Yield of synthesized drug intermediates from H-LTL was found to be 98.88% in ethanol at 90ºC. The synthesized zeolites sample were characterized by the help of FT-IR, XRD, BET Surface Area Analysis and SEM while the synthesis of drug derivatives were confirmed by FT-IR, 1H-NMR and LC-MS.
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