
Oral cancer is a potentially fatal disease with an increasing incidence and an unchanged five years mortality rate. The high mortality rate in cancer such as oral squamous cell carcinoma is commonly attributed to the negligence in detection of the disease at an early treatable stage. A number of promising recent technologies have been proposed to improve the effectiveness of early oral cancer detection. The world health organization has strongly identified prevention and early detection as one of the objectives in the control of oral cancers worldwide. The purpose of this article is to review the current knowledge about the commercially available diagnostic adjuncts in diagnosis of potentially malignant disorders.