Background: The extracts or infusion of Physalis angulata plant fruits were used in the treatment of a wide range of diseases such as asthma, hepatitis, malaria, dermatitis and rheumatism. Aim: The aim of this study was to test the susceptibility of five human pathogenic bacteria species to Physagulin isolated from the fruits of Physalis angulata plant. Methods: The crude extracts were prepared using different solvents by maceration method and isolation, purification were done by TLC and column chromatography. The isolated Physagulin was screened for antibacterial activity using agar well diffusion and broth micro-dilution assay. Results: In the present study, the inhibitory action of the Physagulin was found to increase with an increase in concentration against all bacterial strains. The maximum zone of inhibition was observed at the concentration of 500 µg/ml against all the bacteria. In this study, the S. aureus and E. coli are the more susceptible than the other selected human pathogenic bacteria. Conclusion: Based on the observations, Physalis angulata appears to be a valuable source for antimicrobial properties and helps to produce antimicrobial agents to treat human pathogenic infections.
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