Horizantal gene transfer during which genes are inserted into a genome by viruses, plasmids, and other foreign agents at example of archaea and bacteria cells had been served a more important role in the formation of substrate - substance basis, leading to origin of species during bioevolutionary time, also leading to further creation of NCM medicine and integration of Traditional and Modern medicines, which lasted from October 06 was day (one day is equal to 42 million years) - 3,6 bya years ago until December 31-1:00 a.m (40 mya) first monkeys, 9:00 p.m (5-6 mya) first hominins, 10:30 p.m (2,5 mya) - first stone tools, 11:22 p.m (0,5 mya) -first use of fire, 11:59 p.m (30 000 ya) - Cave paintings, 11:59:35 p.m (12 000 ya) -farming, 11:59:55 p.m (2 000 ya) - common era begins, 11:59:59 p.m (500 ya) -Renaissance. The recent literature date, relating to that archaea and bacteria are the deepest branches of the tree of life, the two groups are similar in morphology and share some fundamental biochemistry, including the genetic code have been confirmed that the day of formation of substrate - substance basis leading to further creation of NCM medicine and integration of Traditional and Modern medicines is October 06 (3,6 bya years ago when life established, first fossils - accorting to a brief evolutionary time table, because in the interval of this day, which lasted 42 million years, had been created the basic elements of membrane - redoxy potentials three state line systems as one is unseparable part of the full 9 stepped cycle of proton, electron conductance inside human body, leading to formation of RNA, DNA, ribosome, genetic code. What about general features of bioevolutional events happened in the October 06, 3,6 bya years ago was the early forms of life establishment in the form of Archea owing to natural geochemically sustained proton gradients of LUCA had been existed in the geochemical origin - hydrothermal vent of this time, giving the fundaments of following appearance of Bacteria, facilitating ecological spread and divergence by Horizantal gene transfer during which genes are inserted into a genome by viruses, plasmids, and other foreign agents at example of archaea and bacteria. The formation of substrate - substance basis during bioevolutionary time, leading to further creation of NCM medicine and integration of Traditional and Modern medicines within October 06 - 3,6 bya years ago had been conducted owing to transformation- the genetic alteration of a cell resulting from the introduction, uptake and expression of foreign genetic material (DNA or RNA. By us have been established that the day of formation of substrate- substance basis leading to further creation of NCM medicine after 3,59 bya years of these historical events and integration of Traditional and Modern medicines is October 06 (3,6 bya, life established, first fossils)- because in the interval of this day, which lasted 42 million years, had been created the basic elements of membrane - redoxy potentials three state line systems as one is unseparable part of the full 9 stepped cycle of proton, electron conductance inside human body, leading to formation of RNA, DNA, ribosome, genetic code. The membrane - redoxy potentials three state line systems formed during October 06 was day (one day is equal to 42 million years) - 3,6 bya years agoas one is unseparable part of the full 9 stepped cycle of proton, electron conductance inside human body, leading to formation of RNA, DNA, ribosome, genetic code had been coded 3000 years ago had been coded by abstract triple code as Khii, Shar, Badgan (K.S.B) in Traditional medicine, when intellectual capacity of humans was developed in high level to find the triple code as (K.S.B).