CALL FOR PAPERS

Author Information

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

Life Sciences / Biology
Architecture / Building Management
Asian Studies
Business & Management
Chemistry
Computer Science
Economics & Finance
Engineering / Acoustics
Environmental Science
Agricultural Sciences
Pharmaceutical Sciences
General Sciences
Materials Science
Mathematics
Medicine
Nanotechnology & Nanoscience
Nonlinear Science
Chaos & Dynamical Systems
Physics
Social Sciences & Humanities

Why Us? >>

Open Access
Peer Reviewed
Rapid Publication
Life time hosting
Free promotion service
Free indexing service
More citations
Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

The ‘ORC’hestral symphony in dna replication across the species

Author:

Sreedevi Padmanabhan

Subject Area:

Life Sciences

Abstract:

The onset of DNA replication which is the essential step in the reproduction of any cell requires specific interactions of initiator proteins at defined loci called origins. Although the origin size varies from prokaryotes to eukaryotes, the origin recognition complex which is one of the major players initiating DNA replication across the species is conserved. The orchestrated binding of ORC facilitates DNA melting which in turn is the inception for the duplication of the DNA thus helping to emanate bidirectionally from the origins. The conserved DNA binding domains, ATP regulation and the structural properties of the DNA are the key features of the replication machinery. The ORC proteins exhibit a multifaceted role besides its fundamental role in DNA replication. The ORC mutations leads to various diseases.

PDF file: