CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

“Protective role of liv.52 on the toxicity of acetaminophen during embryogenesis in wistar rats

Author: 
Santhosh Kumar, D.P., Deecaraman, M., Vijayalaksmi, M., Ramesh Edamula, Krishnappa, H., Latha, M. and GeethaRao, G.
Subject Area: 
Life Sciences
Abstract: 

Acetaminophen induced hepatic injury may also mediate its developmental toxic effects. The present study was carried out to evaluate the protective role of herbal hepato-protective formulation (Liv.52) against acetaminophen induced developmental toxicity (embryo-fetal toxicity and teratogenic potential) in Wistar rats. Acetaminophen induced toxicity during embryogenesis was evaluated by administering daily doses of 500 or 1000 mg/kg/day through oral gavage starting from gestation Day 0 pregnancy until Day 19 of gestation. Dose-dependent decrease in maternal body weights and food intake, gravid uterine weight and total and male/female fetal weights as well as fetal length during gestation were observed in dams exposed to 500 and 1000 mg/kg/dayof acetaminophen. At 1000 mg/kg/day of acetaminophen, dose-dependent decrease in red blood cells, haematocrit, red blood cell distribution width, total number of fetuses and mean litter size were observed. The administration of Liv.52 formulation did not induce any toxic effects during embryogenesis in Wistar rats. However, co-administration of Liv.52 (1000 mg/kg/day) with acetaminophen induced partial or complete reversal of acetaminophen induced developmental toxic effects. In summary, Liv.52 an herbal hepato-protective formulation shown a significant protection against acetaminophen induced developmental toxicity in Wistar rats.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran