CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Adiponectin gene polymorphism snp +276g/t and its association among cardiovascular subjects with diabetes in south India

Author: 
Udyama Juttada, Ramesh Mandarapu, Sudhakar Godi and Paddaiah Gangisetti
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Background and Objective: Adiponectin gene single nucleotide polymorphism (SNP) in the exon 3 and intron 4 is a well characterized SNP which has previously been linked to various diseases including cardiovascular diseases. The association of this gene with cardiovascular disease (CVD) is studied in various studies , hence the present study was designed to investigate the association of SNP +45T/G and +276G/T in the AdipoQ gene in CVD patients with and without diabetes mellitus and normal controls in North Coastal Andhra Population. Methods: The present study has a total 274 subjects, in which group 1 has normal controls without any complications (n=99), group 2 has cardiovascular disease subjects with diabetes (CVDDM) (n=102), and group 3 has cardiovascular disease subjects without diabetes (CVDNDM) (n=73). Patients were divided into group 2 and 3 based on the manifestation of diabetes. All the clinical, biochemical parameters were analysed for the study subjects. Adiponetin SNP were genotyped by PCR-restriction fragment length polymorphism(RFLP). Results: Our study has revealed a significant association of 276G/T adiponectin polymorphism with CVDDM cases in study subjects. The TT genotype against TG+GG genotype of the 276 G/T polymorphism was observed to confer increased risk to develop cardiovascular disease with diabetes (P=0.000001). TT Vs TG+GG in the given population, although the proportion of CVDDM attributable to TT genotype was 6.8% in overall study population, a similar risk factor was also observed in GG genotype against TG+TT genotype to confer the risk of developing cardiovascular disease with diabetes (P=0.0017) and GG genotype attributes nearly 50.9% in overall cases. Whereas heterozygote TG genotype does not show any significant association in CVDDM cases. Conclusion: The SNP 276 G/T of adiponectin gene was observed to confer increased risk to develop cardiovascular disease among diabetes subjects.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran