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Adnan J. M. Al-Fartosy and Ibrahim M. Mohammed

Author: 
Comparison of insulin resistance, prolactin and HbA1c with relation to obesity in men and women of healthy control and diabetic patients / Meisan-Iraq
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Even though the scientific community has started unraveling the mysteries of the close linkage between obesity, insulin resistance, hormones and their physiological effects in diabetic patients, a lot still remains to be discovered. In province of Meisan (southern of Iraq), to date, no study has investigated on obesity, insulin resistance and its effects on type 2 diabetic patients. Therefore, this study embarked on to explore the comparison of insulin resistance, prolactin and HbA1c with relation to obesity in men and women of healthy control and diabetic patients in Meisan province (southern of Iraq). A total of 50 consenting normal individuals (25 men, and 25 women) and 50 adult type 2 diabetic patients (26 men, and 24 women) seen in the central laboratory of Al- Sadder General Hospital and Diabetes and Endocrine Center at the province of Meisan, were evaluated in this cross sectional study. Their fasting glucose, fasting insulin, HbA1c, weight, height, BMI and prolactin were evaluated. Also, insulin resistance parameters (HOMA2-IR, HOMA%B and HOMA%S) were calculated using HOMA2 calculator software. We used student t-test and Pearson’s correlation coefficient to find the statistical significance. On comparison, levels of serum glucose, insulin, HOMA2-IR, BMI, prolactin were significantly (p<0.05) higher as well as level of blood HbA1c (p<0.01) in both men and women type 2 diabetes mellitus cases as compared with those of the controls. On the other hand, there was a positive statistically significant correlation was observed between IR and each of BMI, HbA1c and prolactin, respectively in diabetic patients. The results obtained indicated that increased obesity leads to increased insulin resistance which affected on levels of HbA1c and prolactin in men and women type 2 diabetic patients. Our data indicate that these strong associated between insulin resistance and levels of HbA1c and prolactin could be considered as good biomarkers of the risk of T2D and obesity in men and women type 2 diabetic patients.

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