Advanced periodontal surgeries are amelioration of conventional periodontal surgeries. Advanced periodontal surgeries emphasizes on different regenerative procedures to reconstruct lost hard and soft tissue. It employs combination of 2 or more different surgical procedure, modification in incision & suturing techniques, exploit different materials, and interdisciplinary approach for favorable treatment outcome. This case report illustrating 2 cases with one year follow-up period which had been treated by utilizing principles of advanced periodontal surgeries. First case describes interdisciplinary approach for management of adjacent defect namely: Sieberts class III ridge defect and periapical cyst. Second case is management of palatal perforation associated with large periradicular cyst.