The present study provides information on antioxidant analysis of different extracts of Strychnos nux-vomica leaf. The various parts of Strychnos nux-vomica are recommended for upset stomach, vomiting, abdominal pain, constipation, intestinal irritation, heartburn, insomnia, certain heart diseases, eye diseases, depression, migraine headaches, nervous disorders, problems related to menopause in women and respiratory diseases in the elderly. Different extracts of Strychnos nux-vomica were prepared based on the polarity in solvents of hexane, chloroform, ethyl acetate, acetone and methanol. Among all the solvents used methanol extract of Strychnos nux-vomica showed potential antioxidant properties as tested by the methods of radical scavenging activity. Hence the present exploration of antioxidants studies of Strychnos nux-vomica will be useful in the synthesis and preparation of new drugs of pharmaceutical importance.