Hypodontia and oligodontia are the two most common genetic disorders encountered by dentists on routine oral examination. Hypodontia is the congenital absence of one or less than six teeth and may affect permanent teeth. Probable causes for hypodontia are environmental factors, radiation, trauma, infection and genetic mutations. It is necessary to document such condition to enhance the knowledge about congenitally missing teeth. This paper reports a case of bilateral agenesis of permanent mandibular central incisors in a healthy 12-year-old Indian male patient.