An anti-hyperlipidemic and hypoglycemic effect of kalonji (negilla sativa) in alloxan induced diabetic experimental wistar albino rats

Background: India is facing heavy burden of NCDs (Non-Communicable Diseaes) because of explosion in the epidemiological transition worldwide. In that mainly diabetes, obesity and cardiometabolic risk factors like dyslipidemia plays a important role in the prevalence of NCDs and hence, increase in the cardio vascular events like atherosclerosis and ischemic heart disease. Objective: In present study the effect of Kalonji (Negilla Sativa) seed oil is experimented on cardiometabolic risk factors partly i,e dyslipidemia in alloxan induced diabetic albino rats. Materials and Methods: wistar albino rats of wt 200-250gms were selected and fed with high fat diet for a period of four weeks to induce insulin resistance later direct diabetis was induced by alloxan monohydrate. After induction of diabetes animals fed with standard drug atorvastatin, different doses of Kalonji 200mg/kg, 400mg/kg and 600mg . The data was collected by estimating Bl. glucose levels on day 0, 7, 14 and on 30th day. Lipid profile done with higher dose of kalonji 600/kg body wt. on Day Zero (before treatment) and day 30 (after treatment). Results and Conclusion: It is observed that high dose 600mg/kg body wt. of kalonji showed significant hypolipidemic activity as compare to control and standard drug atorvastatin 10mg/kg body wt. It showed decrease in total cholesterol and LDL levels significantly as that of standard drug Atorvastatin 10mg/kg. And also Hypoglycemic effect of Kalonji at 600mg has shown a potent action as compared to 200mg and 400mg. Kalonji also has not produced any toxic changes with high. Hence kaloonji (negilla sativa) proves that it has both hepato toxicity, rensl toxicity activity which helps in decreasing the risk factors in the development of CVDs and NCDs.