Anti-oxidant and anti-inflammatory activities of barringtonia acutangula linn. bark extracts on rats

Barringtonia acutangula Linn (B.actangula) commonly known as Indian oak is an indigenous medicinal plant which is found throughout India. The objectives of present study are to evaluate the effects of ethanolic and aqueous extracts of B.actangula Linn bark on anti-oxidant and anti-inflammatory properties. The B.actangula bark extracts were prepared by using soxhlet with ethanol and successive aqueous extract was prepared using same marc. The extracts were subjected for phytochemical analysis to identify different phytoconstituents. Acute toxicity study of extracts was carried according to OECD guidelines 423. With the extracts (500mg/kg) anti-oxidant activity property and anti-inflammatory activity was carried out. Antioxidant models such as, ethanol induced oxidative stress in rats and histamine induced oxidative stress in guinea pigs for the estimation of SOD, MDA. Acute and chronic studies of anti-inflammation models like Carrageenan induced paw edema and cotton wool granuloma models were carried out by using extracts of B.acutangula. A significant pharmacological activities of B .acutangula Linn extracts was observed in the present investigation may be due to synergistic potentiative action of its phytoconstituents since, they contain a diverse array of active principles which are able to target multiple mechanisms involved in the pathophysiology of anti-inflammation activities.