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Anti oxidant and anti-inflammatory activities of novel pyrazole derivatives

Author:

Shivaji B. Bole, Nargund L. V. G, Shantharam U, and Vedamurthy, A. B.

Subject Area:

Life Sciences

Abstract:

Series of 5-amino-N-(substituted phenyl)-1-(substituted)-3-[(3-chloro-4-fluorophenyl) amino]-1H-pyrazole-4-carboxamide. Were synthesized from N-(3-chloro-4-fluorophenyl)-2-cyanoa 3, 3 Bis methyl sulfonyl acrylamide using various hydrazines. All the synthesized compounds were characterized by physical data (M.P. & TLC) and spectral Data (IR & 1H NMR). The synthesized compounds were screened for in vitro anti-inflammatory activity by using Diclofenac sodium as standard of concentration (100µg/0.1mL). And in vitro antioxidant activity (300µg/mL). A few of the compounds gave promising results.

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